Many people are told by their GPs or specialists that they are infested by Blastocystis. What these people might not always be aware of is the fact that our intestine is home to billions of organisms, most of which are bacteria. Some bacteria are good for you and help you metabolise food items and synthesise compounds that you cannot produce yourself, while others are associated with disease. Some bacteria are supposed to be there and some are not. Blastocystis is very successfully parasitising on the human intestine, but to our knowledge, there is still no convincing pathogenomic evidence of it causing disease. So, what does it do and why is it there? Does it cause disease at all? How do we get it? We are are trying to find out...
Meanwhile, a lot of effort is being put into collecting stool samples from the background population. There is a project called My Microbes, there's the uBiome project and the American Gut Project, just to mention some. For instance, for less than $100 you can have your entire bacterial intestinal microbiome seqeunced and identified. Maybe, you will even get to know your "enterotype"?!
Below is a brief introduction to the enterotypes (courtesy of My.microbes) that I've been blogging about previously:
Meanwhile, a lot of effort is being put into collecting stool samples from the background population. There is a project called My Microbes, there's the uBiome project and the American Gut Project, just to mention some. For instance, for less than $100 you can have your entire bacterial intestinal microbiome seqeunced and identified. Maybe, you will even get to know your "enterotype"?!
Below is a brief introduction to the enterotypes (courtesy of My.microbes) that I've been blogging about previously:
My.microbes from Anna Pesavento on Vimeo.
It is, however, debatable whether these enterotypes are clear-cut or represent a continuum/gradient. Nevertheless, the prospects of these stupendous microbiome projects are numerous, and once we add the intestinal eukaryotic microbiome to this field and probe into the ecological interplay between eukaryotes, bacteria and the host, new pathways of knowledge will probably lead to many answers to old conundrums, but also to new questions of course. We will get a better impression not only of which bacteria that are beneficial, but also whether - or to which extent - common "scroungers" like Blastocystis are in fact benevolent along some of the lines presented in this recent blogpost.
By the way: Behold the video still: All set for setting up PCR!
Literature:
O’Toole, P. (2012). Changes in the intestinal microbiota from adulthood through to old age Clinical Microbiology and Infection, 18, 44-46 DOI: 10.1111/j.1469-0691.2012.03867.x
Gosalbes, M., Abellan, J., Durbán, A., Pérez-Cobas, A., Latorre, A., & Moya, A. (2012). Metagenomics of human microbiome: beyond 16s rDNA Clinical Microbiology and Infection, 18, 47-49 DOI: 10.1111/j.1469-0691.2012.03865.x
Baquero, F., & Nombela, C. (2012). The microbiome as a human organ Clinical Microbiology and Infection, 18, 2-4 DOI: 10.1111/j.1469-0691.2012.03916.x
Salonen, A., Salojärvi, J., Lahti, L., & de Vos, W. (2012). The adult intestinal core microbiota is determined by analysis depth and health status Clinical Microbiology and Infection, 18, 16-20 DOI: 10.1111/j.1469-0691.2012.03855.x
Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D., Fernandes, G., Tap, J., Bruls, T., Batto, J., Bertalan, M., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M., Kurokawa, K., Leclerc, M., Levenez, F., Manichanh, C., Nielsen, H., Nielsen, T., Pons, N., Poulain, J., Qin, J., Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E., JunWang, ., Guarner, F., Pedersen, O., de Vos, W., Brunak, S., Doré, J., Consortium, M., Weissenbach, J., Ehrlich, S., & Bork, P. (2011). Enterotypes of the human gut microbiome Nature, 474 (7353), 666-666 DOI: 10.1038/nature10187
O’Toole, P. (2012). Changes in the intestinal microbiota from adulthood through to old age Clinical Microbiology and Infection, 18, 44-46 DOI: 10.1111/j.1469-0691.2012.03867.x
Gosalbes, M., Abellan, J., Durbán, A., Pérez-Cobas, A., Latorre, A., & Moya, A. (2012). Metagenomics of human microbiome: beyond 16s rDNA Clinical Microbiology and Infection, 18, 47-49 DOI: 10.1111/j.1469-0691.2012.03865.x
Baquero, F., & Nombela, C. (2012). The microbiome as a human organ Clinical Microbiology and Infection, 18, 2-4 DOI: 10.1111/j.1469-0691.2012.03916.x
Salonen, A., Salojärvi, J., Lahti, L., & de Vos, W. (2012). The adult intestinal core microbiota is determined by analysis depth and health status Clinical Microbiology and Infection, 18, 16-20 DOI: 10.1111/j.1469-0691.2012.03855.x
Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D., Fernandes, G., Tap, J., Bruls, T., Batto, J., Bertalan, M., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M., Kurokawa, K., Leclerc, M., Levenez, F., Manichanh, C., Nielsen, H., Nielsen, T., Pons, N., Poulain, J., Qin, J., Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E., JunWang, ., Guarner, F., Pedersen, O., de Vos, W., Brunak, S., Doré, J., Consortium, M., Weissenbach, J., Ehrlich, S., & Bork, P. (2011). Enterotypes of the human gut microbiome Nature, 474 (7353), 666-666 DOI: 10.1038/nature10187
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